Nilus Lab · AI Drug Discovery Engine

AI Drug Discovery for Human Heart Ageing & Failure

Screening 486,134 single nuclei, proteomic multi-testing gates, and human Mendelian randomisation to isolate causal targets ready for preclinical wet-lab validation.

View Audited Pipeline (4 Confirmed Leads) Evidence Dossiers
Select Preclinical Target (PP):
Zenith v31.0  •  486,134-Cell Litviňuková Adult Heart Atlas (Litviňuková et al., Nature 2020)  •  Research Use Only
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⚡ AI Protocol Discovery
Cardiac Single-Cell Manifold  ·  Research Use Only
Semantic Query
Reprogramming Mode
Gene Lookup UniProt Swiss-Prot
CONF Results Enter Real Scores
Nilus Lab
Population2000
Engine Capacity
Zenith Ultra-v31.0
Main Page
PAPER MAIN PAGE
Micro
PROTOCOL DESIGNSimulation controls
1. Reprogramming Factors
TARGET TRANSCRIPTION
H1FOO-DD (2024 Boost)
MPTR (Nilus Lab Rejuvenation)
Active Factors:
OCT4, SOX2, KLF4, c-MYC
2. Perturbations
3. CRISPR KNOCKOUT
4. Color Analysis
5. Knowledge Integration
Upload papers or protocols. The AI will parse and apply them to the simulation.
3. RENDERING
MICRO-VIEW CONTROLS
VIEWPORT: 2D SIMULATION
CYCLE: FLUORO / PHASE / IMMUNO
RESEARCH LABORATORY
Active Objective
Achieve >150 iPSCs with 0 Tumors
Scenario Presets
Translation Delay (Flux)
GENETIC NOISE0.015
MUTATION PROBABILITY0.05%
TISSUE COHESION (ORGANOIDS)OFF
PROTOCOL POTENCY100%
Actin (Green)
Cytoplasm (Red)
DAPI (Blue)
SIMULATION VISUALIZER2D AGENT MODEL
Entropy--
Cell Viability--
Predictive DriftSTABLE
Identity StabilitySECURE
Mean Mobility0.00 m/s
Visualization Mode
Heuristic Agent-Based Animation (Illustrative Only)
SELECTED CELL
Cell ID--
Type--
Health--
BioAge--
Primary Marker (scVI)--
Epigenetic Stability--%
Signaling Intercept
GNN ACTIVE
Select a cell to intercept paracrine flux...
AI PROTOCOL DISCOVERY Predicted
14 donors · 486,134 atlas · 5,009 genes · 20D latent
MODE: HIGH_FIDELITY_MICROSCOPY
60 FPS
RESEARCH USE ONLY - Phase 1 Validation

Longitudinal Longevity Analysis (RUO)

Patient Digital Twin (Predicted): Zenith-Sim v31.0 | Clinical Profile: #4922-A (Research Use Only)

Current Biological Age
--
Baseline Stabilized
Model ELBO
305.2
[MODEL: scVI reconstruction loss]
Reconstruction MSE
0.023 0.004
[MODEL: 5-fold cross-validation]
Longevity Trajectory (BioAge Over Time)
Cellular Composition
Clinical Observations
Simulating long-term steady state... capture snapshots to see trends.
Protocol Recommendation
Awaiting sufficient longitudinal data points...
V31.0 IN SILICO RESEARCHdX_t = f(X_t, t)dt + g(X_t, t)dW_t | PDB Structure Baseline v1.0 | GRN Inference active
© 2026 NILUS LAB | PROPRIETARY RESEARCH INFRASTRUCTURE | IN SILICO DISCOVERY v33.4 | Boltz-1 Output Terms